Xenopus pancreas development
نویسندگان
چکیده
منابع مشابه
IRE1α is essential for Xenopus pancreas development
Inositol requiring enzyme-1 (IRE1) is highly conserved from yeasts to humans. Upon the endoplasmic reticulum (ER) stress, IRE1 activates X-box-binding protein 1 (XBP1) by unconventionally splicing XBP1 mRNA, which activates the unfolded protein response (UPR) to restore ER homeostasis. In mice, IRE1α inactivity leads to embryonic death and IRE1α plays an essential role in extraembryonic tissues...
متن کاملUltrastructural analysis of some functional aspects of Xenopus laevis pancreas during development and metamorphosis.
Morphological studies using both light and electron microscope were carried out with the aim of characterizing cells present in the larval and adult pancreas of Xenopus laevis. The following cell types have been seen: (1) exocrine cells, with a very well developed r.e.r. (rough endoplasmic reticulum), well defined Golgi complexes and numerous large secretory granules (A cells); (2) cells withou...
متن کاملDevelopment of Artificial Pancreas
Diabetic patients who have an abnormal blood glucose level suffer from acute effects of hypoglycemia and long term effects of hyperglycemia which include disorders of eyes, kidneys and nerves. This paper introduces the concept of an artificial pancreas which is a revolutionary device for the diabetic population. The artificial pancreas (AP), known as closed-loop control of blood glucose in diab...
متن کاملPancreas development and diabetes.
The past few years have seen an increase in interest about the molecular and genetic events regulating pancreas development. Transcription factors such as Pdx1, p48 and Nkx2.2 have been shown to be essential for the proper differentiation of exocrine and endocrine tissue; however, pancreas development also involves intricate interactions between the pancreatic epithelium and its surrounding mes...
متن کاملXenopus as a Model for GI/Pancreas Disease.
Diseases affecting endodermal organs like the pancreas, lung and gastrointestinal (GI) tract have a substantial impact on human welfare. Since many of these are congenital defects that arise as a result of defects during development broad efforts are focused on understanding the development of these organs so as to better identify risk factors, disease mechanisms and therapeutic targets. Studie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2009
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.21935